Osteoarthritis lab opened: rapid and precise diagnosis should expand treatment options

Thursday, October 17, 2024

Osteoarthritis currently affects 1.5 million Dutch people, and this number could rise to 2.5 million by 2040. One of the biggest challenges with this joint condition is the late diagnosis, which leads to incorrect or delayed treatments and ultimately even the need for prosthetics. Engineers from TU Delft and doctors from Erasmus MC are collaborating on a solution: a technology that combines biomechanical analyses with dynamic X-ray imaging.

To realize this technology, they developed a new facility, the 'MOBI-lab,' which can detect osteoarthritis at an early stage. This may eventually enable doctors to initiate the correct treatment immediately, leading to less pain for patients and helping them maintain their mobility for a longer period.

The MOBI-lab is a direct result of the collaboration between Erasmus MC, TU Delft, and Erasmus University Rotterdam within Convergence Health & Technology. What began as an initiative a few years ago, spun off from the collaboration in the scientific program Medical Delta: Improving Mobility with Technology, is steadily growing.

Complete picture of disruptions in the joint

“In the MOBI-lab, we combine dynamic X-ray fluoroscopy with biomechanical motion analysis to visualize how joints are stressed during daily activities such as (jogging) and cycling,” says Jaap Harlaar, Professor of Clinical Biomechanics (TU Delft) and Medical Delta Professor. “The X-ray fluoroscopy captures the joint movement, while the cartilage load is determined by biomechanical motion analysis. This unique combination of medical expertise from Rotterdam and technological innovation from Delft provides in-depth insight into osteoarthritis and enables research that is not available anywhere else in the world.”

“Thanks to the combined expertise of doctors and engineers, we developed this facility that is at the forefront of early detection of osteoarthritis. With advanced MRI and PET-MRI scans, we can detect damage to joints and abnormal cartilage quality at an earlier stage, even before the cartilage has worn away,” says Edwin Oei, Professor of Musculoskeletal Imaging. “By combining this with data from the MOBI-lab, we obtain a complete picture of the disruptions in the joint. This allows us to recognize osteoarthritis earlier and treat patients more effectively, significantly improving their quality of life.”

 

Collaboration between doctors and engineers

Due to the strategic location of the lab in the heart of the hospital, doctors and researchers can not only detect early-stage osteoarthritis with unprecedented precision but also collaborate in real-time on innovative solutions and implement the correct treatment more quickly. This makes the implementation more efficient, allows for faster scaling, and enables patients to benefit sooner from new diagnostic methods and treatments. 

Read more on the websites of TU Delft and Convergence

Watch the introductory videos below from Medical Delta professors Jaap Harlaar (from 2021) and Sita Bierma-Zeinstra (from 2022) about research on osteoarthritis:

 

 

 

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