The Faculty of Science and the Leiden Academic Centre for Drug Research (LACDR) are looking for a:
PhD candidate, Computational modelling of cytokine networks in T cells
Are you an expert in the development of computational models that describe the dynamics of biological systems, aiming to apply such models to real-world biological data? As part of our enthusiastic team you will employ computational dynamical modelling approaches in order to understand cytokine-mediated regulation in T cells and their effect on tumour targets. Within our team at the Leiden Academic Centre for Drug Research (LACDR) we are looking to hire a PhD student to develop such models and apply them to experimental data on T cells, target cells and their interactions, acquired by experimental collaborators.
T cells play an important role in guarding us against invading pathogens and cancer progression. Cytokines are key factors in the communication between T cells and other cells, and their production is tightly regulated through intricate regulatory mechanisms. However, these regulatory networks are highly complex and intertwined, making it difficult to intuitively understand how they function and contribute quantitatively to immune responses.
In this ZonMW-funded PhD project, computational models will be developed to provide a quantitative understanding of cytokine regulatory networks in T cells at molecular level, and how they affect T cells themselves as well as tumour targets at population level. To this purpose, computational models ranging from ordinary differential equation models to spatially explicity agent-based models will be developed. These models aim to describe experimental measurements by Monika Wolkers’ lab (Amsterdam UMC/Sanquin) on cytokine responses at mRNA and protein level in single cells, and on cell population level responses like cell proliferation and cell death. Note that the work of the PhD student is purely computational, but close collaboration with experimentalists generating the data is required.
Click here for the full job description and application procedure.
Submission is possible until 14 June 2026
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